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Poxet 90 mg is a medication that contains dapoxetine, which is primarily used to treat premature ejaculation (PE) in men. While I can provide some general information, it's important to consult with a healthcare professional for personalized advice regarding the use of Poxet 90 mg and any potential contraindications. Poxet 90 mg is not recommended for individuals with certain medical conditions due to potential interactions and increased risk of adverse effects. Poxet is primarily metabolized in the liver and excreted through the kidneys. Individuals with severe liver or kidney disease may have impaired drug metabolism and elimination, which can increase the risk of side effects or affect the effectiveness of the medication. Healthcare professionals may need to adjust the dosage or consider alternative treatments in these cases. Poxet 90 mg should be used with caution in individuals with certain mental health disorders, such as bipolar disorder or severe depression, as it can potentially worsen these conditions. Close monitoring by a healthcare professional is recommended in these cases. These are not the only medical conditions that may require caution or avoidance of Poxet 90 mg. It's important to disclose your complete medical history, including any ongoing medical conditions or medications, to your healthcare professional. They can assess the potential risks and benefits of using Poxet 90 mg in your specific case and provide appropriate recommendations based on your individual circumstances.